Saturday 

Manchester United vs Manchester City
12:30 Sky Main event 

One of the most competitive big derbies in the world over the last decade. City and United have played 30 times, with 13 wins each and four draws. Always a big game, this encounter will have the added drama of Ronaldo facing City for the first time since he snubbed them to rejoin United.

RB Leipzig vs Borussia Dortmund
17:30 Sky Sports MIX

It’s no secret that Leipzig and under-fire coach Jesse Marsch have been struggling this season. However, they’ll be looking to build on a strong midweek showing against PSG as they face a Dortmund side battling an extensive injury list that includes start striker Haaland. Will young big man Steffen Tigges step up and bring the goals in his place?

Real Madrid vs Rayo Vallecano
20:00 La Liga TV

A Madrid derby, of sorts. Vallecano and Real operate on different ends of the spectrum in almost every way conceivable, and it would mean a hell of a lot for the relative minnows of Vallecano to win at the Bernabau for the first time this millennium. And with 35-year-old Falcao rolling back the years and averaging under a goal every 90 minutes, it’s very much a possibility.

Sunday 

Everton vs Tottenham Hotspur
14:00 Sky Sports Main Event

Conte’s first Premier League test comes with a tricky away trip to Goodison Park to face Rafa Benitez’s Everton. With both sides sitting solidly mid-table, this looks set to be a key game in both side's push for the top 6. Expect a tactically fascinating encounter.

West Ham vs Liverpool
16:30 Sky Sports Main Event

It’s almost six years since West Ham last beat Liverpool in the league, and the reds will be hoping West Ham’s so far indifferent home form this season will continue as they look to reel in Chelsea at the top of the table. West Ham meanwhile are looking to put further breathing space between them and the chasers in the hunt for the top 4.

AC Milan vs Inter
19:45 BT Sport 1 

A lot has changed since Milan and Inter last met in February. While it was a comfortable 3-0 win for soon-to-be champions Inter on that occasion, it’s Milan who go into this tie as favourites. Undefeated and hot on the heels of Napoli, this could be a huge game for Stefano Pioli’s men.

Real Betis vs Sevilla
20:00 La Liga TV/Eleven Sports

There are few derbies in Spain that stir up the passion of Sevilla Betis. The atmosphere inside Betis’ Estadio Benito Villamarín will be electric as Betis look to stop any possibility of their rivals going top of the league with a win.